肉漫屋

朱华庆教授，肉漫屋 生物化学与分子生物学教研室教授，安徽省教学名师，安徽省特支计划人选，肉漫屋 生物医学工程肉漫屋 副院长。

1993年－1997年  安徽大学，     生命科肉漫屋 ，本科/学士

1999年－2002年  肉漫屋 ， 肉漫屋 ，研究生/硕士

2004年－2007年  肉漫屋 ， 药理研究所，研究生/博士

2008年－2010年  加拿大西安大略大学，心血管内科学，博士后

1997年－2002年  肉漫屋 ，肉漫屋 ， 助教

2002年－2007年  肉漫屋 ，肉漫屋 ， 讲师

2007年－2011年  肉漫屋 ，肉漫屋 ， 副教授

2011年－至今       肉漫屋 ，肉漫屋 ， 教授

1. 项目名称  特异性非编码RNA作为早期动脉粥样硬化新型生物标志物及临床价值研究；安徽省重点研发项，2020年1月至2022年12月，批准文号： 202004b11020025；30万元；

2. 项目名称  microRNA-29b对早期AS动脉内皮功能的影响及其调控机制；国家自然科学基金面上项目，2016年1月至2019年12月，批准文号 ：81570419；57万元；

3. 项目名称  miRNA126调控AS发生发展中动脉内膜通透性变化及其分子机制；国家自然科学基金面上项目，2013年1月至2016年12月，批准文号 ：81270372；75万元；

4. 项目名称  miR1调控apoE基因敲除鼠内皮细胞MLCK表达及分子机制；国家自然科学基金面上项目，2011年1月至2013年12月，批准文号： 81070232；33万元；

1. Wang GX, Sun GC, Wang Y, Yu P, Wang X, Zhou BR*, Zhu HQ*. Glabridin attenuates endothelial dysfunction [and] permeability, possibly via the MLCK/pMLC signaling pathway. Exp Ther Med. 2019; 17: 107-114

2. Tang ST, Tang HQ, Su H, Wang Y, Zhou Q, Zhang Q*, Wang Y*, Zhu HQ*. Glucagon-[like] peptide-1 attenuates endothelial barrier injury in diabetes via cAMP/PKA mediated down-regulation of MLC phosphorylation. Biomedicine & Pharmacotherapy. 2019;113:108667

3. Wu Y#, Wang XB#, Zhou Q, Wang Y, Zhou J, Wang Y*, Zhu HQ*. ATRA improves endothelial dysfunction in atherosclerosis by decreasing CAV1 expression [and] enhancing eNOS activity. Mol Med Rep. 2018 ; 17:6796-6802

4. Lu Z#, Wang F#, Yu P, Wang X, Wang Y, Tang ST*, Zhu HQ*. Inhibition of miR-29b suppresses MAPK signaling pathway through targeting SPRY1 in atherosclerosis. Vascul Pharmacol. 2018;1537-1891(17)30284-7

5. Tao LL#, Nie YM#, Wang GX, Ding Y, Ding JL, Xiong FY, Tang ST, Wang Y, Zhou BR*, Zhu HQ*. All trans retinoic acid reduces endothelin 1 expression [and] increases endothelial nitric oxide synthase phosphorylation in rabbits with atherosclerosis. Mol Med Rep. 2018; 17(2): 2619-2625. 

6. Xiong FY, Tang ST, Su H, Tang HQ, Jiang P, Zhou Q, Wang Y*, Zhu HQ*. Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long term diabetic cardiomyopathy. Mol Med Rep. 2018; 17(1):374-381.

7. Tang ST#，Wang F#，Shao M#，Wang Y*，Zhu HQ*，MicroRNA-126 suppresses inflammation in endothelial cells under hyperglycemic condition by targeting HMGB1，Vascul Pharmacol. 2017.01.10，88(1)：48~55

8. Cheng XW#, Wan YF#, Zhou Q, Wang Y*, Zhu HQ*. MicroRNA126 inhibits endothelial permeability [and] apoptosis in apolipoprotein Eknockout mice fed a highfat diet. Mol Med Rep. 2017;16(3):3061-3068.

9. Tao LL，Zhu J，Chen Y，Wang Q，Pan Y，Yu Q，Zhou BR*，Zhu HQ*.IL-35 improves Treg-mediated immune suppression in atherosclerotic mice, Exp Ther Med. 2016.10.12，12(4)：2469~2476

10. Tang ST，Zhang Q，Tang HQ，Wang CJ， Zhou Q，Wei W，Zhu HQ*，Wang Y*，Effects of glucagon-[like] peptide-1 on advanced glycation endproduct-induced aortic endothelial dysfunction in streptozotocin-induced diabetic rats: possible roles of Rho kinase- [and] AMP kinase-mediated nuclear fact[or] κB signaling pathways，Endocrine，2016.07.13，53(1)：107~116

11. Tang ST， Zhang Q，Tang HQ，Wang CJ，Zhou Q，Wei W，Zhu HQ*， Wang Y*，Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-κB/IκBα system through the activation of AMP-activated protein kinase，Int J Mol Med，2016； 37(6)：1558~1566

12. Wu Y, Qi YJ, Liu H, Wang XS, Zhu HQ*, Wang ZG*. AMPK activat[or] AICAR promotes 5-FU-induced apoptosis in gastric cancer cells. Mol Cell Biochem. 2016 ;411(1-2):299-305. 

13. Shao M#, Tang ST#, Liu B*, Zhu HQ*. Rac1 mediates HMGB1induced hyperpermeability in pulmonary microvascular endothelial cells via MAPK signal transduction. Mol Med Rep. 2016 ;13(1):529-35.

14. Tang ST#, Su H#, Zhang Q, Tang HQ, Wang CJ, Zhou Q, Wei W, Zhu HQ*, Wang Y*. Melatonin Attenuates Aortic Endothelial Permeability [and] Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- [and] MLCP-Dependent MLC Phosphorylation. J Cardiovasc Pharmacol Ther. 2016 ;21(1):82-92

15. Wang Y, Wang F, Wu Y, Zuo L, Zhang SM, Zhou Q, Wang Y*, Zhu HQ*. MicroRNA-126 attenuates palmitate-induced apoptosis by targeting TRAF7 in HUVECs. Mol Cell Biochem. 2015; 399(1-2):123-30.

16. Cheng XW#, Wang XB#, Wan YF, Zhou Q, Zhu HQ*, Wang Y*. Myosin light chain kinase inhibit[or] ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis. Mol Med Rep. 2015;12(3):4109-16

17. Cheng XW#, Wan YF#, Xu Y, Wang Y*, Zhu HQ*. Melatonin alleviates myosin light chain kinase expression [and] activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits. Mol Med Rep. 2015; 11(1):99-104.

18. Zhu HQ*, Li Q, Dong LY, Zhou Q, Wang H*, Wang Y.  MicroRNA-29b promotes high-fat diet-stimulated endothelial permeability [and] apoptosis in apoE knock-out mice by down-regulating MT1 expression. Int J Cardiol. 2014; 176(3):764-70.

19. Zhu HQ*, Wang F, Dong LY, Zhou Q, Wang Y*.  MicroRNA1 modulates oxLDL- induced hyperlipidemia by down-regulating MLCK [and] ERK/p38 MAPK pathway. Life Sci. 2014; 107(1-2):21-6.

20. Zhu HQ*#, Wang XB#, Han JX, Hu ZP, Wang Y, Zhou Q, Gui SY, Wang Y*. Myosin light chain kinase inhibit[or] attenuates atherosclerosis [and] permeability via reduced endothelial tight junction in rabbits. Int J Cardiol. 2013; 168(5):5042-5043.

21. Wang H, Zhu HQ*, Wang F, Zhou Q, Gui SY, Wang Y*. MicroRNA-1 prevents high-fat diet-induced endothelial permeability in apoE knock-out mice. Mol Cell Biochem. 2013; 378(1-2):153-159.

22. Zhu HQ#, Yang YX#, Wang YP, Li J, Schiller PW, Peng T*. MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1. Cardiovasc Res. 2011; 92(1):75-84.

23. Zhu HQ, Zhou Q, Jiang ZK, Gui SY, Wang Y*. Association of aorta intima permeability with myosin light chain kinase expression in hypercholesterolemic rabbits. Mol Cell Biochem. 2011; 347(1-2):209-215.

24. Li JM#, Zhu HQ#, Shen E #, Wan L, Arnold JM, Peng T*. Deficiency of Rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress [and] reduces myocardial remodeling in type-I diabetic mice. Diabetes. 2010; 59(8):2033-42.

25. Zhu HQ, Shan LM, Schiller PW, Mai A, Peng T*, Histone deacetylase-3 activation promotes tum[or] necrosis factor-alpha (TNF-alpha) expression in cardiomyocytes during lipopolysaccharide stimulation. J Biol Chem. 2010; 285(13): 9429-36

26. Zhu HQ, Shan LM, Peng T*. Rac1 mediates sex difference in cardiac tum[or] necrosis factor-alpha expression via NADPH oxidase-ERK1/2/p38 MAPK pathway in endotoxemia. J Mol Cell Cardiol. 2009; 47(2): 264-74.